Domperidone is a medicine that is commonly used to treat symptoms of nausea and vomiting.

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What is Domperidone?

Domperidone tablets contain domperidone as the active ingredient; this substance belongs to a group of medicines known as dopamine antagonists.

It is an anti-sickness medicine that comes in the form of a tablet or liquid.

It is available to order at MedsOnline247, following an online consultation (questionnaire) with one of our certified clinicians. If you order with us before 2pm, your order will be shipped the same day.

What is Domperidone used to treat?

Domperidone is used as a treatment for nausea and vomiting. It can also be used to alleviate stomach pain if you are having end of life care (palliative care). Other common uses are when your stomach cannot empty food as normal otherwise known as gastroparesis and is useful for those who suffer with heartburn or gastro-oesophageal reflux disease (GORD/GERD).

Domperidone has been shown to significantly increase prolactin levels in most (although possibly not all) lactating mothers. It is not licensed as a galactogogue, but is considered the treatment of choice to enhance breast milk supply in specific circumstances when recommended by a midwife or specialist.

It works by blocking the messages that are passed between the brain and the digestive system.

This causes the muscles at the exit of your stomach to relax, reducing the likelihood of you being sick.

Domperidone is also able to block messages sent between parts of your brain known as the chemoreceptor trigger zone (CTZ) and the vomiting centre. This prevents nausea and vomiting and can be particularly useful in motion or travel sickness.

Who can use Domperidone?

Domperidone is an effective treatment for nausea and vomiting, but it may not be suitable for everyone to use.

This medication is only recommended for adults and adolescents aged 12 years old and above.

In some cases, it is prescribed for babies and young children, but only by a specialist doctor.

You should inform your doctor if any of the following conditions apply to you before you start to use this medicine:

  • You weigh less than 35kg
  • You have ever had bleeding from your stomach or gut
  • You have ever had an allergic reaction to domperidone or any other medicine in the past
  • You have any conditions caused by a bowel obstruction, such as Crohn’s disease or diverticulitis
  • You have a tumour in your pituitary gland
  • You have an irregular heartbeat
  • You have liver, kidney or heart problems
  • You have recently had abdominal surgery

Please note, this list is not exhaustive. For a list of rarer and more serious adverse effects you may experience, please refer to the Side Effects tab on this page.

Domperidone Dosage

Always use Domperidone exactly as instructed by your doctor or pharmacist. Read the patient information leaflet thoroughly before you start your course of treatment. Speak to your doctor or pharmacist if you are not sure of how to take it.

Domperidone is for oral consumption only. Each tablet should be swallowed whole with a glass of water. Do not crush or chew the tablets.

Take Domperidone 15 to 30 minutes before you eat a meal and, if required, before you go to bed.

Adults and children over 12 years old

The usual dose is one tablet, to be taken 3 times a day, ideally before a meal.

Do not take more than 3 tablets a day.

If you have any kidney problems, your doctor may instruct you to take a lower dose or to take Domperidone less often.

How long will I need to take it?

Your nausea and vomiting symptoms will normally be resolved within 3-4 days of taking this medicine.

You should not take Domperidone tablets for longer than 7 days, unless you have been advised to do so by your doctor.

What if I forget to take it?

If you accidentally miss a dose of Domperidone, take the medication as soon as you remember, as long as it is not almost time for your next scheduled dose.

If it is almost time for your next dose, skip the missed dose and continue taking Domperidone as usual.

Do not double dose to try and make up for a missed dose.

What if I take more than I am supposed to?

Taking too much Domperidone can be dangerous to your health.

Taking more than the prescribed dose can result in a fast or irregular heartbeat.

If you or someone else has taken too much Domperidone, you should call 111 or speak to your doctor for advice straight away.

Domperidone Side Effects

Below is a list of side effects which can occur when you use this medication. It is not known how frequently these reactions may occur.

Speak to your doctor if you find you suffer from any of the following:

  • Enlarged breasts in men
  • Upward movement of the eyes
  • You are unable to urinate
  • There are changes in certain laboratory test results
  • A stop in menstrual periods in women
  • Restless legs syndrome
  • Depression

Serious allergic reaction

In some cases, patients may find that they suffer from a serious allergic reaction after they have used this medicine.

You should call 999 or go to A&E straight away if you have any of the following symptoms:

  • You are wheezing
  • You have swelling in your mouth, lips, tongue, face or throat
  • You are finding it hard to speak or breathe
  • You have tightness in your chest or throat
  • You have a skin rash that is red, blistered, swollen, itching or peeling skin

You might require immediate treatment in hospital.

Can you buy Domperidone in the UK?

Yes, it is available to purchase from a pharmacy when you have a prescription from a doctor. You can buy Domperidone at MedsOnline247, following an online consultation with one of our certified clinicians, who will assess your symptoms and prescribe Domperidone if they find it to be the right treatment for your condition. Never order from anywhere other than a pharmacy that is registered with the General Pharmaceutical Council (GPhC) and registered with the MHRA to purchase Domperidone. UK registered pharmacies like MedsOnline247 can guarantee genuine prescriptions from registered doctors/clinicians, as well as genuine medicine when you order from us. If you order with us before 2pm, we will ship your order the same day.

How do you take Domperidone?

Always follow your doctor’s instructions when taking a prescription medicine. If you have any questions, speak to them for more information. Domperidone should be swallowed whole with a drink of water. Adults and children over 12 years old should take one tablet 3 times a day, ideally before a meal. Do not take more than 3 tablets a day. People who have kidney problems may be told to use a lesser dose. You should find your symptoms improve after 3-4 days. Do not keep taking the medicine for longer than 7 days.

Can I still drink alcohol?

It is not thought that alcohol interacts directly with this treatment. However, alcohol can exacerbate feelings of nausea and digestive discomfort, so you should not consume alcohol if you are taking this medication.

Will I still be able to drive?

Yes, but only if you experience no side effects which may make doing so dangerous. If you do, avoid driving and consult your doctor for advice as soon as possible.

Can I use this medicine while pregnant?

It may not be suitable in these cases. Talk to your doctor in person if you are pregnant or breastfeeding, as they may need to suggest an alternative form of treatment.

How do I store it?

Make sure this item is kept in an environment below 25°C, and safely out of the reach of children.

Am I allergic to anything in the medicine?

This product contains: domperidone maleate, microcrystalline cellulose, lactose monohydrate, maize starch, povidone K30, sodium lauryl sulphate, silica colloidal anhydrous, and magnesium stearate.

Do not use it if you are allergic to any of these ingredients.

Is it available over-the-counter?

You will require consultation with a doctor before you are able to buy Domperidone from any UK pharmacy. This is so that they can make sure it is safe for you to use.

How can I buy Domperidone online?

If you haven’t taken Domperidone before, speak to your doctor in person before using it for the first time.

To renew your prescription for Domperidone, take our questionnaire. Your order will be checked by one of our UK registered prescribers, who will issue a prescription for you on approval, and send this to our pharmacy to be dispensed. Shipping on all orders is made by tracked courier, so you can follow the progress of your parcel.