Evorel Sequi


Evorel Sequi is known as ‘continuous sequential’ HRT, as it contains the female hormones, oestrogen and progestogen, released on a sequence. First, oestrogen is released on its own for two weeks, and then it’s released together with progestogen for two weeks. These hormones work to replenish a woman’s natural levels and offset the effects of menopause.

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Buy Evorel Sequi Patches Online

You can order Evorel Sequi patches online from our UK registered online pharmacy and doctor service. After completing a questionnaire, our prescribers will review your order. If approved, our pharmacy team will dispense and dispatch your medication to your chosen address using discreet packaging. Our delivery options include standard and next day delivery.

What is Evorel Sequi?

Evorel Sequi is a Hormone Replacement Therapy (HRT). It is used to relieve symptoms associated with the menopause. It can also be used in post-menopausal women at risk of osteoporosis.

HRT uses oestrogen to replace the lost oestrogen from the effects of the menopause. Most HRT products also contain a progestogen.

Evorel Sequi packs contain Evorel 50 (oestrogen-only patches) and Evorel Conti (oestrogen + progestogen patches). A treatment cycle is 28 days. During the first 14 days, Evorel 50 patches are worn and during the next 14 days, Evorel Conti patches are worn.

Evorel Sequi is called a continuous sequential HRT preparation.

How does it work?

Levels of the female sex hormone oestrogen drop during the menopause. This drop causes symptoms of the menopause like night sweats, hot flushes, reduced sex drive, mood swings, and vaginal dryness.

Evorel patches contain the active ingredient estradiol which is an oestrogen. This is absorbed through the skin and into the bloodstream. This replaces the oestrogen lost during the menopause and relieves symptoms.

Taking oestrogen increases the risk of womb cancer because oestrogen causes an overgrowth of the endometrium (womb lining). Using a progestogen alongside an oestrogen protects against this increased risk of womb cancer. For that reason, most HRT products such as Evorel Sequi contain both an oestrogen and progestogen (estradiol and norethisterone). Women who have had their womb removed are able to take oestrogen-only HRT.


The patches should be applied to a hairless area of the body below the waist, it must not be applied on or near the breasts. Patches should not be applied to the same area twice in a row. They should be worn under loose-fitting clothing.

Instructions on how to apply the patch are on page 10 of the patient information leaflet.

Evorel Sequi patches must be changed twice per week but they have to be used in the right order.

  • For the first two weeks of the pack, Evorel 50 patches should be used (changed twice per week, four patches in total).
  • For the third and fourth week of the pack, Evorel Conti patches should be used (changed twice per week, four patches in total).

If a patch falls off, replace it with the same type of patch. It is always useful to have a spare pack to replace any patches that fall off.


Other forms of HRT include:

  • Vaginal creams
  • Vaginal gels
  • Tablets
  • Vaginal pessaries
  • Gels

Our doctors are able to prescribe the following HRT tablets:

  • Elleste Solo
  • Estring
  • Elleste Duet
  • Elleste Duet Conti
  • Evorel Conti
  • Trisequens
  • Provera
  • Estradot
  • Premique
  • Kliovance
  • Vagifem
  • Premarin
  • Livial
  • Prempak C

Various HRT products have suffered from long term shortages in the past two years. The products can differ slightly, making it hard to find a direct alternative when one is out of stock.

There are no direct alternatives to both Evorel Conti and Evorel Sequi. To achieve a similar dose an oestrogen-only patch (e.g Evorel 50) or gel (e.g Oestrogel) should be used alongside progestogen tablets (e.g Provera tablets).

Common side effects of Evorel Sequi include:

  • Nausea
  • Headache
  • Problems sleeping
  • Diarrhoea
  • Breast tenderness
  • Irritated skin where the patch is applied
  • Weight gain

These side effects may improve over time when using Evorel patches.

The patient information leaflet for Evorel Sequi contains further information on the side effects of HRT.

HRT can be very beneficial for women with menopause symptoms however, there are potential risks associated with treatment. The following diseases are reported more often in women taking HRT compared to women not taking HRT:

  • Breast cancer
  • Stroke
  • Endometrial (womb) cancer
  • Heart disease
  • Ovarian cancer
  • Blood clots (venous thromboembolism)

Oestrogen-only HRT has an increased risk of womb cancer but HRT containing progestogens, like Evorel Sequi, protects against this risk.

The risk of blood clots in HRT users is highest during the first year of treatment. The increased risk is up to 3x higher in users of HRT compared with non-users.

The risks of taking HRT may be different in women who have early menopause. If this is the case for you, you should discuss these risks with your doctor.

There is evidence to suggest HRT use increases the risk of breast cancer. The risk increases the longer HRT is taken for. This increased risk returns to normal within about 5 years of stopping treatment.

Patients should be routinely monitored by their doctor during HRT treatment. Treatment with HRT should only be started if the benefits outweigh the risks and doctors should take a full medical history before prescribing. Further information can be found on the NHS website for breast cancerblood clots,  stroke and endometrial cancer as well as information on the risks of HRT.

Are Evorel Sequi and Evorel Conti patches still available?

There has been a low supply of Evorel Sequi and Evorel Conti stock in recent months due to manufacturing issues. However, both products are currently in stock.

How long does it take for Evorel Sequi to work?

The benefits of HRT treatment on symptoms can be seen within a few weeks but it may take up to 3 months for the full benefits of HRT to take effect.

Do HRT patches make you gain weight?

Some HRT products may cause weight gain as a side effect. The manufacturers of Evorel Sequi note that weight gain is a common side effect of the patches.

Can I delay a period on Evorel Sequi?

Evorel Sequi is a continuous sequential HRT. This type of HRT will give a ‘withdrawal bleed’ like a period every month around week 4 of the patches. If you would like advice about delaying a period please discuss this with the relevant healthcare professionals, like your GP or pharmacist.

When should I bleed on Evorel Sequi?

A withdrawal bleed will start during the 4th week of the cycle before you finish the pack.

Can I order Evorel Sequi online?

Yes, you can Evorel Sequi online via our UK registered online pharmacy and doctor service. After having an online consultation, our prescribers can assess your suitability for treatment and issue a prescription if necessary.